Over the past 25 years, we have witnessed vast scientific advances. Such advances, including functional magnetic resonance imaging (fMRI), have great implications of assisting and improving the treatment of addiction(s). Regrettably, despite these scientific advances, deep rooted deep rooted stigmas and misconceptions remain. This presentation will describe possible predisposing factors and undercurrents of addiction, the basic neurobiology of addiction, and adaptive coping skills.